Extractive Spectrophotometric Determination of some Drugs Through Ion-Pair Complex Formation with Thiocyanate wnd Cobalt (II) or Molybdenum (V)

Two rapid, simple and sensitive extractive specrophotometric methods has been developed for the assay of Hyoscine butyle bromide (HBB), losartan potassium (LSR) and Sertaline HCl (SER) in bulk and in their pharmaceutical formulations. The proposed methods depend upon the reaction of cobalt(II)–thiocyanate (method A) and molybdenum(V)–thiocyanate ions (method B) with the cited drugs to form stable ion-pair complexes which is extractable with an n-butnol–dichloromethane solvent mixture (3.5:6.5) and methylene chloride for methods A and B, respectively. The blue and orange red color complexes are determined either colorimetrically at λmax 625,627 and 630 nm for HBB,SER and LSR respectively (using method A) and 478 , 465 and 468 nm for HBB,SER and LSR respectively (using method B). The concentration range is 20–400 and 5–50 gmL � −1 for methods A and B, respectively. The proposed method was successfully applied for the determination of the studied drugs in pure and pharmaceutical formulations applying the standard additions technique and the results obtained were in good agreement with those obtained by the official method. [Ragaa El-Shiekh, Magda Akl, Ayman Gouda and Wael Ali. Extractive Spectrophotometric Determination of some Drugs Through Ion-Pair Complex Formation with Thiocyanate wnd Cobalt (II) or Molybdenum (V). Journal of American Science 2011;7(4):794-807]. (ISSN: 1545-1003). http://www.americanscience.org.